A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.
نویسندگان
چکیده
We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 127 38 شماره
صفحات -
تاریخ انتشار 2005